Cincinnati, Ohio
The first clues that the Queen City — a Rust Belt capital that was hard hit by the decline of American manufacturing — was poised for a comeback started a few years ago, when tech startups and small businesses moved into disused Over-the-Rhine warehouses, filmmakers flocked in to take advantage of tax breaks and early-20th-century architecture, and historic spaces like the city’s Music Hall got a much-needed polish. Now, the urban revival is official — but sneak in a 2021 visit and you can still claim to be a trendsetter. Check into the Kinley, which opened its doors in downtown Cincy in October with a much-buzzed-about restaurant from chefs Kevin Ashworth and Edward Lee. While you’re in town, dine at restaurant standouts Please and Goose & Elder, explore new outdoor installations at the Cincinnati Art Museum, and pay a visit the lauded Cincinnati Zoo, whose animal dispatches on social media are the only reasonable justification for keeping your Twitter account. —Lila Battis
Delaware
Over the past year, Delaware has been making headlines as the de facto HQ for No. 46 and his transition team, but there’s plenty of reason for buzz beyond politics. Many of the recent developments that have drawn young professionals to the capital of Wilmington from nearby hubs like Philadelpha — creative businesses, a high-caliber culinary scene, fewer crowds — also appeal to travelers. Wilmington’s marquee hotel, Hotel DuPont, recently underwent a multi-million dollar refurbishment that breathed new life into its iconic Green Room, which now houses the refined French restaurant Le Cavalier, and added De.CO, a casual food hall with six stalls and a bar. Sartorially inclined visitors would do well to check out wares from Town and Store Studio. (For the time being, designer Liv McClintock is selling her handmade leather goods and jewelry via pop-ups and trunk shows.) And though Torbert Street Social is temporarily closed to adhere to COVID restrictions, the recent addition to Wilmington’s cocktail scene is worth a stop for such well-crafted originals as the LL Mule J, which pairs vodka with blood orange and kombucha. Come summer, it’ll be hard to stay away from the revitalized Riverfront area, which encompasses a number of seafood joints and provides access to watersports and local walking trails. — Sarah Bruning
Denver’s Lower Highlands
When you visit a city, you want to be based where the cool crowd is. In Denver, that means the hip, arty Lower Highlands neighborhood. LoHi, as it’s known by locals, has long been the city’s hub for creative cocktails, craft breweries, and cult restaurants, like Pan-Latin small plates spot Señor Bear and Israeli hit Ash’Kara. In the face of a pandemic, the hood has loyally supported exciting newcomers including Fifth String, a restaurant focused on family-style dishes and natural wines, and Room for Milly, a cocktail bar inspired by the roaring 20s. The recent addition of 17-room Life House Lower Highlands finally gives visitors an option beyond Airbnb if they want to be immersed in the LoFi action. Located in the heart of the Navajo Street Art District, the intimate stay transports guests to a Victorian-era pioneer homestead — but, y’know, cool — with furnishings upholstered in dusty florals, Wild West nods like cowhide detailing and vintage cowboy photos, and a sexy, saloon-inspired restaurant and bar. Through an exclusive partnership with conservation-minded land management group Ranchlands, guests can escape the city for a day and experience the frontier spirit firsthand at Chico Basin Ranch. For a jolt of 21st century culture, downtown Denver is just short walk away and will unveil a massive art installation from New Mexico-backed artist collective Meow Wolf later this year. —Jen Murphy
Florida’s Middle Keys
The closest you can get to a Caribbean vacation without leaving the continental U.S., the laid-back islands between Key Largo and Key West took the brunt of Hurricane Irma in 2017 and are where you want to visit in 2021 to connect with one of the country’s most fragile ecosystems, both above and below sea level: astronomer-led stargazing walks at the family-friendly Hawk’s Cay on Duck Key; Grimal Grove, where community organizer-turned-tropical fruit farmer Patrick Garvey is raising five varieties of nutritious breadfruit to fight hunger insecurity; the Turtle Hospital on Marathon, whose recent 911s include caring for babies beached by Hurricane Eta and endangered Kemps-Ridleys cold-stunned (like hypothermia for turtles) in Cape Cod. While unseasonably chilly water spells trouble up north, warming seas and a still-unidentified infection has bleached up to 98 percent of the Keys’ local reef — the largest in North America — but the young scientists at the MOTE Elizabeth Moore marine lab on Summerland Key are in the midst of a promising project to rejuvenate the crippled reef through lab reproduction (like IVF for coral). You can even participate in a hands-on underwater coral transplant through a new partnership with Captain Hook’s dive center on Big Pine. To balance good work with sybaritic indulgence, there’s no beating the scalloped pool and impeccable residences at Marathon’s recently reopened Marlin Bay Resort & Marinaz. The resort is walking distance to Keys Fisheriesz, the best place in the islands for stone crab, a sustainable specialty that goes for $3 a claw in season at the pleasingly disheveled upstairs bar. —Adam Erace
Fort Worth, Texas
A walloping dose of Texas heritage — with some luxe, modern updates — is drawing visitors to hit the city where the West begins. The historic Fort Worth Stockyards, once a resupply stop for cattle drovers, captures the celebrated legacy of Texas’ bustling livestock industry with rodeos, a history museum, and the world’s only twice-daily cattle drive. It’s also home to an array of boutiques rich with Lone Star style: In Mule Alley, visit Lucchese for a pair of hand-stitched boots, and stop at Stetson for the obligatory cowboy hat. The forthcoming Hotel Drover, too, will pay homage to the cowboys of old. Set to open in early 2021, the property has a design sensibility that’s Old West-meets-Spanish Colonial, with a sprinkling of Victorian smoking lounge moodiness. Embark on a tour of the city’s booming creative scene with stops at Art Tooth and the recently renovated Amon Carter Museum of American Art, then cap off your evening with some of Texas’s best grain-to-glass bourbon at Blackland Distilling. Stay overnight at the soon-to-open Hotel Dryce, a posh, locally owned boutique hotel and bar situated in Fort Worth’s Cultural District. — Gabrielle Nicole Pharms
