1. Alaska’s Coast
In the midst of the pandemic, Alaska's entire May to September cruise season was cancelled in 2020. That left some 1.3 million travelers unable to board ships to experience thunderously calving glaciers, frolicking humpback whales, lively gold rush towns, and fascinating Alaska Native arts scenes. Tourism providers missed serious income. Cruise lines and local officials express muted optimism about 2021, which may be the best year to see Alaska given that cruise ships are unlikely to sail full and coastal towns won't have their typical crowds even post-vaccine rollout. Or skip the civilization part: Vast national parks such as Glacier Bay, Misty Fjords, and Kenai Fjords are best reached by boat. Small ship soft-adventure lines such as UnCruise Adventures and Lindblad Expeditions — and ultra-luxurious Seabourn with its zodiac and kayak exploration program on the 450-passenger Seabourn Odyssey — have one-week itineraries that spend most of their time in the wild. For more privacy, rent the six-passenger, 78-foot Sea Mist for a luxury yachting experience in Prince William Sound, home to more active tidewater glaciers than anywhere else in the world. — Fran Golden
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2. Astoria, Oregon
Goonies never say die, and neither does the nostalgia of visiting Astoria, the northwestern Oregon town at the mouth of the Columbia River where the '80s cult classic film was shot. The oldest American settlement in the West, this charming seaside town evokes a simpler time with its colorful Victorian houses and treasure-filled antique shops. Around these parts, freshness matters only for fish and beer. A new mobile passport program by the North Coast Craft Beer Trail ensures drinkers find their way to both big names like Fort George Brewery — famous for its IPAs — and smaller spots like the 20-barrel Buoy Beer, built in a former fish cannery right on the river. It's one of many old cannery sites that have found new lives here, most notably the boutique Cannery Pier Hotel, where new ownership plans a February unveiling of renovations to its spa — famed for the Finnish sauna and water-view hot tub. Though the town made its name on tinned fish, Astoria now thrives on the direct connection to fresh seafood at places like South Bay Wild Fish House, from the family behind a fishing vessel of the same name. At their restaurant, sustainably caught Dungeness crab, Oregon pink shrimp, black cod, and more goes direct from boat to bánh mì. — Naomi Tomky
3. The Berkshires
City-dwellers have been visiting this region of gently rolling hills and charmingly sedate towns in Western Massachusetts since the 19th century, but a welcome boost of youthful energy arrived with the 2018 opening of the design-forward hotel Tourists in North Adams and, last year, the launch of Miraval Berkshires, the third location of the luxe wellness resort. While summer is still the most popular season, thanks in part to the beloved classical music venue Tanglewood and dance center Jacob’s Pillow, there are still plenty of opportunities for social distancing, from the enormous exhibition spaces at the contemporary art museum Mass Moca, to the pastoral acres surrounding the Clark Art Institute (home to the Institute’s first-ever outdoor exhibition, Ground/work, through October 2021), to a hike up Mount Greylock or Monument Mountain, to a meal at Cantina 229, a restaurant set on a farm that offers outdoor seating in warmer months. Mooncloud, a new bar in Great Barrington, is riding out the pandemic with a slate of to-go meals and cocktail kits. Tuck in for the night at the peaceful but chic Inn at Kenmore Hall, a bed and breakfast in a classical Georgian estate. —Peter Terzian
4. Big Sky, Montana
Big Sky’s 5,800 acres of skiable terrain makes it a fan favorite for crowd-free skiing in the Rocky Mountains. But a multi-year, $150 million investment into Big Sky Resort aims to transform this region of Southwest Montana into America’s Alps, meaning skiers may soon have to share their powder-perfect runs. Last year, The Wilson Hotel, a Residence Inn by Marriott, made headlines when it became the first and only major brand hotel to open in Big Sky’s town center (don’t miss the soon-to-open Tips Up, a vintage-inspired tavern across the street). Now, all eyes are on the $400 million ultra-luxury Montage Big Sky, which will open its doors for the 2021-22 ski season within Spanish Peaks Mountain Club, a 3,500-acre private golf and ski community. The 150-key resort features ski-in, ski-out access, an 11,000-square-foot spa, and a four-lane bowling alley. In warmer climes, guests can enjoy the development’s 18-hole golf course, nearby fly-fishing rivers, and an extensive network of hiking and mountain biking trails. Two slope-side hotels, the Summit and the Huntley Lodge, have renovations in the works, and Moonlight Basin, another private development adjacent to the ski resort, has plans to build a luxury hotel (a One&Only if the rumors are true) on its 8,000-acre-property, which is also home to a thousand-acre high-elevation Jack Nicklaus signature golf course. New airlift is ushering travelers from Nashville, Fort Lauderdale, and Charlotte, N.C. to Bozeman Yellowstone International Airport (less than an hour’s drive from downtown Big Sky), while a new six-person high-speed chairlift will begin whizzing people up Lone Peak in record time starting next November. When the snow melts, Big Sky’s 18-mile proximity to Yellowstone National Park adds even more appeal for nature lovers in search of epic adventures in the great outdoors. Just be sure to get there before everyone else does. — Nora Walsh
5. Birmingham, Alabama
The modern scene in The Magic City is a great example of what can happen with when Alabama kids head off to the big city to hone their skills, then return home to do their thing — in a really high-quality way. Take Chef Adam Evans: the Muscle Shoals native worked in New Orleans and New York and opened The Optimist with Ford Fry in Atlanta before heading back to B-Ham to launch Automatic Seafood & Oysters. Moves like this — along with quirky java shops (Red Cat Coffee House), upscale cocktail bars (Paper Doll), a women-owned vegan food truck, and the Pizitz global food hall — have brought a vibrancy to the city, where contemporary charm and old Southern hospitality mingle on a big scale. The destination is catching up to demand for luxury lifestyle hotels with the Valley Hotel, opening in the historic, cool-again suburb Homewood in January with a new outpost of Edgar’s Bakery and more restaurants to come. Railroad Park, a 19-acre green space, has transformed downtown over the last decade, with walking trails, food truck festivals, and an outdoor symphony. And look for Protective Stadium, a 47,000-seat facility and entertainment district, to open in 2021. —Kelsey Ogletree